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KMID : 0606920090170030270
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Biomolecules & Therapeutics
2009 Volume.17 No. 3 p.270 ~ p.275
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Attenuated Cerebral Ischemic Injury by Polyethylene Glycol-Conjugated Hemoglobin
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Cho Geum-Sil
Choi Yoo-Keum
Kim Seul-Ki
Cai Ying
Lee Jae-Chul
Nho Kwang
Choi In-Young
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Abstract
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Polyethylene glycol-conjugated hemoglobin (PEG-Hb) has been proposed as a blood substitute for transfusion due to their plasma expansion and oxygen transport capabilities. The protective effect of PEG-Hb on cerebral hypoxic-ischemic injury was investigated in neonatal hypoxia model and adult rat focal cerebral ischemia model. As intravenously administered 30 min before the onset of hypoxia, PEG-Hb markedly protected cerebral hypoxic injury in a neonatal rat hypoxia model. A similar treatment of PEG-Hb largely reduced the ischemic injury ensuing after 2-h middle cerebral artery occlusion followed by 22-h reperfusion. Consistently, neurological disorder was significantly improved by PEG-Hb. The results indicate that the pharmacological blockade of cerebral ischemic injury by using PEG-Hb may provide a useful strategy for the treatment of cerebral stroke.
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KEYWORD
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Polyethylene glycol-conjugated hemoglobin, Hypoxia, Focal cerebral ischemia
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